공지사항
[2025] 제3회 SNUBIC Art Fair Series 워크샵
작성자
admbic
작성일
2025-08-21
조회
22
주최: 서울대학교 뇌영상센터(SNUBIC)
과제명: 인프라 고도화: 고경사 확산 자기공명 영상장치 도입을 통한 뇌 구조와 기능에 대한 난제 해결(RS-2024-00435727)
후원: 국가연구시설장비진흥센터(NFEC), 교육부
- 행사명 : SNUBIC ART FAIR SERIES #3
- 행사 일시 : 8/24(목) 11:00-12:00
- 행사 장소 : 서울대학교 28동 303호
- 연사: 최승홍 교수(서울대학교 의과대학 영상의학과)
- 발표 제목: Visualizing Glymphatic Pathways: Innovative MRI Approaches for Flow Analysis
- Abstract:
The glymphatic system has emerged as a critical facilitator of metabolic waste clearance in the central nervous system, with implications for neurodegenerative disease pathogenesis and brain homeostasis. Traditional methods for studying glymphatic function have relied on invasive procedures or exogenous tracers, limiting their utility for translational and clinical applications. Recent advances in magnetic resonance imaging (MRI) have enabled non-invasive assessment of glymphatic transport and provided unprecedented insights into the spatial and temporal dynamics of cerebrospinal fluid (CSF) and interstitial fluid (ISF) flow.
In this talk, I present innovative MRI methodologies to visualize and analyze glymphatic pathways in vivo, focusing on techniques such as diffusion tensor imaging (DTI), intrathecal contrast-enhanced MRI, and dynamic contrast-enhanced MRI. These approaches allow for quantitative and qualitative evaluation of glymphatic function, including tracer movement, perivascular transport, and regional differences in CSF-ISF exchange.
Utilizing advanced image processing and modeling algorithms, we were able to delineate the perivascular spaces and measure fluid propagation through brain parenchyma with high spatial resolution. Our findings demonstrate that glymphatic flow patterns are markedly influenced by physiological states such as sleep, anesthesia, and exercise. Moreover, alterations in glymphatic transport were observed in models of aging and neurodegenerative conditions, highlighting the clinical relevance of MRI-based glymphatic visualization.
The incorporation of dynamic imaging protocols enabled us to capture the real-time kinetics of solute clearance and revealed regional heterogeneity in glymphatic function across cortical and subcortical structures. Notably, these novel MRI techniques correlate with traditional histological and tracer-based measurements, validating their utility for preclinical and potential clinical investigation.
In conclusion, our study underscores the significance of innovative MRI approaches for elucidating glymphatic system physiology and pathophysiology. The ability to non-invasively visualize and quantify glymphatic pathways represents a major advancement in neuroimaging, with substantial implications for early diagnosis and monitoring of brain disorders associated with impaired waste clearance. These methods have the potential to accelerate translational research and guide therapeutic strategies targeting glymphatic dysfunction.
In this talk, I present innovative MRI methodologies to visualize and analyze glymphatic pathways in vivo, focusing on techniques such as diffusion tensor imaging (DTI), intrathecal contrast-enhanced MRI, and dynamic contrast-enhanced MRI. These approaches allow for quantitative and qualitative evaluation of glymphatic function, including tracer movement, perivascular transport, and regional differences in CSF-ISF exchange.
Utilizing advanced image processing and modeling algorithms, we were able to delineate the perivascular spaces and measure fluid propagation through brain parenchyma with high spatial resolution. Our findings demonstrate that glymphatic flow patterns are markedly influenced by physiological states such as sleep, anesthesia, and exercise. Moreover, alterations in glymphatic transport were observed in models of aging and neurodegenerative conditions, highlighting the clinical relevance of MRI-based glymphatic visualization.
The incorporation of dynamic imaging protocols enabled us to capture the real-time kinetics of solute clearance and revealed regional heterogeneity in glymphatic function across cortical and subcortical structures. Notably, these novel MRI techniques correlate with traditional histological and tracer-based measurements, validating their utility for preclinical and potential clinical investigation.
In conclusion, our study underscores the significance of innovative MRI approaches for elucidating glymphatic system physiology and pathophysiology. The ability to non-invasively visualize and quantify glymphatic pathways represents a major advancement in neuroimaging, with substantial implications for early diagnosis and monitoring of brain disorders associated with impaired waste clearance. These methods have the potential to accelerate translational research and guide therapeutic strategies targeting glymphatic dysfunction.
- 간단 소개: 글림프계(glymphatic system)은 뇌 대사 노폐물 제거를 담당하는 중요한 체계로, 그 기능 저하는 신경퇴행성 질환 발병과 뇌 항상성에 직결됩니다. 이번 세션에서는 DTI, 동적 조영증강 MRI, 척수강 조영 MRI와 첨단 영상처리 및 모델링 알고리즘을 통해 글림프계 기능을 정량화 하는 최신 방법을 다룹니다. 서울대학교 뇌영상센터의 핵심 연구자인 최승홍 교수님께서는 이 분야의 선도 연구자로서, Cima.X의 고해상도 확산영상을 이용한 글림프계 연구 분야의 난제 접근 방법을 소개하실 예정입니다.
