- 행사명: SNUBIC ART FAIR SERIES #1
- 일시: 2025.07.24(목요일) 10:30AM~
- 장소: 서울대학교 28동 303호
- 연사: 이종호 교수(서울대학교 공과대학 전기전자공학부)
- 발표 제목: Advanced diffusion and myelin imaging
- Abstract:
In this talk, I will introduce and explain several advanced neuroimaging techniques that go beyond conventional diffusion tensor imaging (DTI) to offer deeper insights into brain microstructure. Specifically, I will cover three widely used diffusion MRI methods—Neurite Orientation Dispersion and Density Imaging (NODDI), Diffusion Kurtosis Imaging (DKI), and Diffusion Spectrum Imaging (DSI)—as well as a myelin imaging technique based on magnetic susceptibility source separation, also known as χ-separation.
NODDI provides a model-based framework for estimating neurite density and orientation dispersion, making it useful for assessing both gray and white matter integrity. DKI quantifies the non-Gaussian behavior of water diffusion, enabling sensitive detection of microstructural complexity and tissue heterogeneity. DSI, a model-free technique, reconstructs the full diffusion propagator in q-space, allowing it to resolve complex fiber configurations such as crossing and kissing fibers with high angular resolution.
In addition to these diffusion-based methods, I will present χ-separation, a novel technique that disentangles magnetic susceptibility sources—primarily iron and myelin—by leveraging their distinct biophysical contributions to the MR signal. This method enables quantitative and source-specific mapping of myelin, providing complementary information to diffusion metrics in understanding brain structure and pathology.
By comparing the principles, strengths, and applications of these techniques, this talk aims to highlight their synergistic roles in advancing both basic neuroscience and clinical neuroimaging.